Antibody-dependent priming of spontaneous germinal centers by autoreactive B cells
Danny Kim, Kristy Chiang, Andrea D. Largent, Ragan A Pitner, Sivasankaran Munusamy Ponnan, Brock J. McKinney, Richard G. James, David J. Rawlings, Shaun W. Jackson
This study shows autoreactive B cells can initiate spontaneous germinal centers and autoimmunity through antibody-dependent mechanisms, independent of T cell interactions or antigen presentation.
bioRxiv · Sep 1, 2026 · PreprintImmunology