Andrea D. Largent

This study shows autoreactive B cells can initiate spontaneous germinal centers and autoimmunity through antibody-dependent mechanisms, independent of T cell interactions or antigen presentation.

This paper identifies MAPK signaling and MYC-driven suppression of p21 as mechanisms of vincristine resistance in fusion-negative rhabdomyosarcoma and shows that dual targeting of MAPK and BCL-XL pathways overcomes resistance.