Author

Brock J. McKinney

Fred Hutch Cancer CenterORCID 0009-0002-2170-6048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Andrea D. LargentiD· 1 shared Anna-Lena B.G. VigiliD· 1 shared Ayaha ItokawaiD· 1 shared Danny Kim· 1 shared David J. RawlingsiD· 1 shared Douglas B. FoxiD· 1 shared James V. AlvareziD· 1 shared Josh Wu· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

Andrea D. LargentORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Antibody-dependent priming of spontaneous germinal centers by autoreactive B cells

Danny Kim, Kristy Chiang, Andrea D. Largent, Ragan A Pitner, Sivasankaran Munusamy Ponnan, Brock J. McKinney, Richard G. James, David J. Rawlings, Shaun W. Jackson

This study shows autoreactive B cells can initiate spontaneous germinal centers and autoimmunity through antibody-dependent mechanisms, independent of T cell interactions or antigen presentation.

bioRxiv · Sep 1, 2026 · PreprintImmunology

Recurrent Breast Cancer Cells Depend on De novo Pyrimidine Biosynthesis to Suppress Ferroptosis

Kelley R. McCutcheon, Josh Wu, Yasemin Ceyhan Ozdemir, Brock J. McKinney, Sharan Srinivasan, Ayaha Itokawa, Oliver J. Newsom, Anna-Lena B.G. Vigil, Douglas B. Fox, Lucas B. Sullivan, James V. Alvarez

This study identifies de novo pyrimidine synthesis as a metabolic vulnerability in recurrent breast cancer cells that suppresses ferroptosis, with DHODH inhibition selectively targeting these cells.

bioRxiv · Nov 17, 2025 · PreprintCancer Biology