ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle
Amber Crabtree, Mohd Mabood Khan, Estêvão Scudese, Calixto Pablo Hernandez Perez, Prasanna Venkhatesh, Andrea Gail Marshall, Benjamin Rodriguez, Edgar Garza Lopez, Okwute Michael Ochayi, Estélio Henrique Martin Dantas, Pamela Martin, Matheus Baffi, Fabiana Rodrigues Scartoni, Margaret Mungai, Kit Neikirk, , Antentor Othrell Hinton Jr.
This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.
bioRxiv · Mar 30, 2026 · PreprintCell Biology