Cell BiologybioRxivPreprint
ATF4 Coordinates Transcriptomic and Structural Adaptations in Aging Muscle
Amber Crabtree, Mohd Mabood Khan, Estêvão Scudese…·Antentor Othrell Hinton Jr.
This study shows ATF4 coordinates transcriptomic and structural changes in aging muscle, linking it to mitochondrial dysfunction and suggesting the ISR pathway as a therapeutic target.