Regulation of mitochondrial proteostasis by the proton gradient
Maria Patrón, Daryna Tarasenko, Hendrik Nolte, Lara Kroczek, Mausumi Ghosh, Yohsuke Ohba, Yvonne Lasarzewski, Zeinab Alsadat Ahmadi, Alfredo Cabrera‐Orefice, Akinori Eiyama, Tim Kellermann, Elena I. Rugarli, Ulrich Brandt, Michael Meinecke, Thomas Langer
The paper shows that the mitochondrial proton gradient regulates the m-AAA protease AFG3L2 through TMBIM5, linking protein turnover to mitochondrial energy status and Ca2+ signaling.
The EMBO Journal · Aug 1, 2022Peer-reviewedMolecular Biology