Ulrich Brandt

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

The paper investigates the pathogenic mutation m.10191T>C in mitochondrial DNA, showing it leads to reduced complex I function and NADH accumulation, contributing to Leigh syndrome.

CompaCt integrates complexome profiling data across species to identify conserved and species-specific protein complexes and interactions, improving characterization through comparative analysis.

The paper shows that the mitochondrial proton gradient regulates the m-AAA protease AFG3L2 through TMBIM5, linking protein turnover to mitochondrial energy status and Ca2+ signaling.

The paper identifies a previously overlooked complex between AIFM1 and cytochrome c oxidase using mass spectrometry and proteomic approaches, revealing structural insights and potential roles in OXPHOS and cell death.

CEDAR provides a database for complexome profiling data with standardized formats, a web interface, and tools for analysis and exploration.

COPAL aligns complexome profiles to identify changes in mitochondrial protein complex abundance caused by Barth syndrome mutations.