Maria Patrón

This study identifies AFG3L2-mediated proteolysis as a mechanism that restricts mitochondrial biogenesis and gene expression under hypoxia by degrading key mitochondrial proteins.

This study maps the MCU-mediated mitochondrial calcium signaling network using proteomics, identifying 89 new interactors and their roles in disease-related pathways.

The paper shows that the mitochondrial proton gradient regulates the m-AAA protease AFG3L2 through TMBIM5, linking protein turnover to mitochondrial energy status and Ca2+ signaling.