Yvonne Lasarzewski

Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15

The paper shows OMA1 regulates mitochondrial protein import and OXPHOS biogenesis under stress by degrading DNAJC15, affecting protein translocation and organelle communication.

AFG3L2-mediated proteolysis restricts mitochondrial biogenesis and gene expression in hypoxia

This study identifies AFG3L2-mediated proteolysis as a mechanism that restricts mitochondrial biogenesis and gene expression under hypoxia by degrading key mitochondrial proteins.

Regulation of mitochondrial proteostasis by the proton gradient

The paper shows that the mitochondrial proton gradient regulates the m-AAA protease AFG3L2 through TMBIM5, linking protein turnover to mitochondrial energy status and Ca2+ signaling.