The BAF complex works with FOS to regulate human neuronal activity-dependent ASD-associated gene programs
Sara K. Trowbridge, GiHun Choi, Ava C. Carter, Jillian E Petrocelli, Josephine E Robb, Gabriel T. Koreman, Siwei Chen, Ryan N. Doan, Christopher P. Davis, David A. Harmin, Eric C. Griffith, Konrad J. Karczewski, J. Wade Harper, Michael E. Greenberg
This study identifies BAF complex interaction with FOS in regulating ASD-associated gene programs through enhancer activation and shows how genetic variants disrupt this process.
bioRxiv · Aug 27, 2026 · PreprintNeuroscience