Author

David Brown

Genomics EnglandPrimary ORCID profile (0000-0002-5524-7276 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

David BrowniD3 papers · J. Craig Venter Institute

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Adam Shlien· 1 shared Adriana MañasiD· 1 shared Aleksandra AdamskaiD· 1 shared Alexandra SegeriD· 1 shared Anne Lefort· 1 shared Antonia LockiD· 1 shared Cesare Spadoni· 1 shared Chiara LagoiD· 1 shared

Activity by Year

2015-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Adam Shlien

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma.

Katarzyna Radke, Kristina E. Aaltonen, Erick Andrés Muciño-Olmos, Javanshir Esfandyari, Aleksandra Adamska, Joachim T. Siaw, Dora Adamič, Chiara Lago, Adriana Mañas, Alexandra Seger, Karin Hansson, Oksana Rogova, Sophie Lehn, Daniel J. Mason, Daniel J O’Donovan, , Daniel Bexell

This study repurposes statins and phenothiazines to treat chemoresistant neuroblastoma, showing synergistic effects and improved survival in preclinical models.

EMBO Molecular Medicine · Dec 23, 2025Peer-reviewedCancer Biology

Harnessing the 100,000 Genomes Project whole genome sequencing data - an unbiased systematic tool to filter by biologically validated regions of functionality

Sihao Xiao, Zhentian Kai, David Brown, Claire L. Shovlin

The paper develops a filter called GROFFFY to prioritize functional genomic variants from whole genome sequencing data, reducing variant numbers while retaining clinically relevant variants.

medRxiv · Mar 30, 2020 · PreprintGenetic & Genomic Medicine

Principles governing A-to-I RNA editing in the breast cancer transcriptome

Debora Fumagalli, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, David Brown, Naima Kheddoumi, Adam Shlien, Tomasz Konopka, Roberto Salgado, Denis Larsimont, Kornelia Polyak, Karen Willard-Gallo, Christine Desmedt, Martine Piccart, , Vincent Detours

This study identifies ADAR expression and inflammation as key regulators of A-to-I RNA editing in breast cancer, showing increased editing frequency in tumors and its impact on cell proliferation and apoptosis.

Cell Reports · Oct 1, 2015Peer-reviewedGenomics