Designed NGF mimetics with reduced nociceptive signatures in neurons
Thomas Schlichthaerle, Aerin Yang, Damien Detraux, David E. Johnson, Chloe J. Peach, Natasha I. Edman, Catherine M Sniezek, Charles A. Williams, Sonali Arora, Neerja Katiyar, Irene Chen, Ali Etemadi, Andrew Favor, David S. Lee, Connor A. Kubo, , David A. Baker
The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.
bioRxiv · Apr 14, 2025 · PreprintBiochemistry