Chloe J. Peach

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

The paper compares the spatiotemporal dynamics of TrkA, TrkB, and TrkC using biosensors, finding distinct signaling and trafficking behaviors, particularly for TrkC isoforms.

This study shows that targeting protease-activated receptor 2 (PAR2) signaling in organelles using nanomedicines provides sustained analgesia in preclinical models of inflammatory bowel disease.

The paper identifies a druggable EP2 receptor in Schwann cells that encodes PG-mediated persistent inflammatory pain without affecting protective inflammation.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study investigates GRPR endosomal signaling in pruritus and shows that endosomal targeting of GRPR antagonists is more effective in blocking itch sensation.

This paper identifies NRP1 as a co-receptor for NGF and TrkA pain signaling and shows that targeting NRP1 or GIPC1 can reduce chronic pain without opioid use.