Author

Charles A. Williams

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Jessica E. YoungiD· 3 shared Aerin YangiD· 1 shared Aleah Rosner· 1 shared Alex KangiD· 1 shared Ali EtemadiiD· 1 shared Ananya Govindarajan· 1 shared Andrew FavoriD· 1 shared Aquene N. ReidiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Jessica E. YoungORCID

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Author profile →

3 papers

Recent·Most cited

RhoGEF12 regulates endosomal SORL1-retromer and its inhibition is therapeutic in human neuronal models of Alzheimer's disease

Yasir H. Qureshi, Charles A. Williams, István Hajdú, Suvarnambiga Kannan, Ananya Govindarajan, Barbara M. Végh, Gregory A. Petsko, Jessica E. Young, Péter Závodszky, Scott A. Small

Pharmacological inhibition of RhoGEF12 increases endosomal SORL1-retromer recycling and reduces pathogenic amyloid secretion in human neuronal models, identifying a novel, targetable pathway for treating Alzheimer's disease.

bioRxiv · Mar 9, 2026 · PreprintNeuroscience

Evaluating Microglial Contributions to the Neurovascular Unit in Health and Neurodegeneration Using Human In Vitro Models

Kira M. Evitts, Emily Turschak, Charles A. Williams, Chizuru Kinoshita, Aleah Rosner, Willow Battista, Katherine Hui, Ian H. Beck, Aquene N. Reid, YING ZHENG, Jessica E. Young

This study develops 2D and 3D human in vitro neurovascular unit models to investigate microglial interactions with endothelial cells and their role in neurovascular function under inflammatory conditions.

bioRxiv · Dec 22, 2025 · PreprintCell Biology

Designed NGF mimetics with reduced nociceptive signatures in neurons

Thomas Schlichthaerle, Aerin Yang, Damien Detraux, David E. Johnson, Chloe J. Peach, Natasha I. Edman, Catherine M Sniezek, Charles A. Williams, Sonali Arora, Neerja Katiyar, Irene Chen, Ali Etemadi, Andrew Favor, David S. Lee, Connor A. Kubo, , David A. Baker

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

bioRxiv · Apr 14, 2025 · PreprintBiochemistry