Author

David J. Stone

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:simulation· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Afina Willemina LemstraiD· 2 shared Andrew SingletoniD· 2 shared Cornelis BlauwendraatiD· 2 shared Dena G. HernandeziD· 2 shared Ekaterina A. RogaevaiD· 2 shared Eliezer MasliahiD· 2 shared Elisabet LondosiD· 2 shared Geidy E. SerranoiD· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Afina Willemina LemstraORCID

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Author profile →

3 papers

Recent·Most cited

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

Ruth Chia, Marya S. Sabir, Sara Bandrés‐Ciga, Sara Sáez-Atiénzar, Regina Hertfelder Reynolds, Emil Karl Gustavsson, Ronald L. Walton, Sarah Ahmed, Coralie Viollet, Jinhui Ding, Mary B. Makarious, Mónica Díez-Fairén, Makayla K. Portley, Zalak Shah, Yevgeniya A. Abramzon, , Thomas G. Beach

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

bioRxiv · Jul 6, 2020 · PreprintGenomics

Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease

Hampton L. Leonard, Cornelis Blauwendraat, Lynne Krohn, Faraz Faghri, Hirotaka Iwaki, G. D. Ferguson, Aaron Day-Williams, David J. Stone, Andrew Singleton, Mike A. Nalls, Ziv Gan‐Or

This study simulates clinical trials to show genetic differences between trial arms can lead to false negatives and positives, especially in small samples, and suggests genetic balancing improves outcomes.

Journal of Medical Genetics · Nov 29, 2019Peer-reviewedGenomics

Heritability and genetic variance of dementia with Lewy bodies

Rita João Guerreiro, Valentina Escott‐Price, Dena G. Hernandez, Célia Kun‐Rodrigues, Owen A. Ross, Tatiana Orme, João Luís Neto, Susana Carmona, Nadia Dehghani, John D. Eicher, Claire E. Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, , José Brás

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

Neurobiology of Disease · Apr 3, 2019Peer-reviewedNeuroscience