ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart
Shijie Liu, Seth T. Gammon, Lin Tan, Yaqi Gao, Kyoungmin Kim, Ian Williamson, Janet Pham, Angela Davidian, Radhika Khanna, Benjamin D. Gould, Rebecca Salazar, Heidi Vitrac, An Q Dinh, Evan C. Lien, Francisca N. de Luna Vitorino, , Anja Karlstaedt
This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.
bioRxiv · Jun 21, 2024 · PreprintMolecular Biology