DNA barcoding for parallelised single-molecule characterisation of kinetic phenotypes
Stefan H. Mueller, David M. Grimson, Holden Paz, Aidan C. Fitch, Haibo B. Yu, Marco Ribezzi‐Crivellari, Andrew D. Griffiths, Antoine M. van Oijen, Lisanne M. Spenkelink
This paper introduces a DNA barcoding method to simultaneously profile kinetic properties of protein variants at the single-molecule level, revealing kinetic diversity and structural subpopulations.
bioRxiv · Aug 28, 2025 · PreprintBiophysics