Human SYNGAP1 Regulates the Development of Neuronal Activity by Controlling Dendritic and Synaptic Maturation
Nerea Llamosas, Vineet Arora, Ridhima Vij, Murat Kılınç, Łukasz Bijoch, Camilo Rojas, Adrian M. Reich, BanuPriya Sridharan, Erik Willems, David R. Piper, Louis D. Scampavia, Timothy Spicer, Courtney A. Miller, Jimmy Lloyd Holder, Gavin Rumbaugh
This study shows that SYNGAP1 loss-of-function in human neurons leads to enhanced dendritic morphogenesis, increased excitatory synapses, and altered network activity.
bioRxiv · Jun 1, 2020 · PreprintNeuroscience