Murat Kılınç

The paper introduces Endo-GeneScreen, a platform that identifies small molecules regulating endogenous protein levels, and demonstrates its application in finding probes for Syngap1-related neurodevelopmental disorder.

This study shows that SYNGAP1 loss-of-function in human neurons leads to enhanced dendritic morphogenesis, increased excitatory synapses, and altered network activity.

The paper investigates SynGAP splice variants' spatio-temporal expression and subcellular distribution in the developing mammalian brain, finding isoform-specific patterns and localization changes.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

This study shows that restoring SynGAP protein in adult Syngap1 heterozygous mice improves memory, seizure susceptibility, and brain activity patterns.