Camilo Rojas

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

This study shows that Syngap1 haploinsufficiency in mice causes opposing cortical activity patterns, with reduced sensory responses and increased movement/arousal activity, revealing cell-type-dependent effects on network states.

This study shows that Syngap1 in cortical neurons is essential for sensorimotor integration and perception by shaping neural dynamics and connectivity.

This study shows SYNGAP1, an autism risk gene, is expressed in human cortical progenitors and its dysfunction disrupts neurogenesis and cortical lamination.

The paper shows that specific SynGAP splice variants improve cognitive function and reduce seizures in mice.

This study shows that SYNGAP1 loss-of-function in human neurons leads to enhanced dendritic morphogenesis, increased excitatory synapses, and altered network activity.

This study shows Syngap1 regulates plasticity of silent neurons in the somatosensory cortex during sensory experience, with implications for neurodevelopmental disorders.

The paper investigates how the SynGAP-1 PBM regulates NMDA receptor signaling and cognitive function in mice, finding that disrupting the PBM leads to synaptic and cognitive impairments.

This study shows that restoring SynGAP protein in adult Syngap1 heterozygous mice improves memory, seizure susceptibility, and brain activity patterns.