Long range mutual activation establishes Rho and Rac polarity during cell migration
Henry De Belly, Andreu F. Gallen, Evelyn Strickland, Dorothy C. Estrada, David Sanchez Godinez, Eric Neiva, Patrick J. Zager, Tamas L. Nagy, Janis K. Burkhardt, Hervé Turlier, Orion David Weiner
The paper reveals a long-range mutual activation mechanism between Rho and Rac GTPases that establishes polarity during cell migration, conserved in epithelial cells and essential for T cell migration.
Nature Cell Biology · Jun 1, 2026Peer-reviewedCell Biology