Author

David Sprott

University Hospital Carl Gustav Carus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Andreas LinkermanniD· 1 shared Angela Rösen‐WolffiD· 1 shared Björn H. FalkenburgeriD· 1 shared Claudia GüntheriD· 1 shared David Geißler-LöschiD· 1 shared Éva M. SzegőiD· 1 shared Felix SchulzeiD· 1 shared Hella LukschiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Andreas LinkermannORCID

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1 paper

Recent·Most cited

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Éva M. Szegő, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann, Rayk Behrendt, Lino Lars Teichmann, Björn H. Falkenburger, Angela Rösen‐Wolff

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

eLife · Mar 20, 2025Peer-reviewedImmunology