Björn H. Falkenburger

The paper shows that TFEB activation restores lysosomal function and improves motor neuron survival in SMA, highlighting its potential as a therapeutic target.

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

This study shows that constitutively active STING in mice leads to neuroinflammation and dopaminergic neuron degeneration, suggesting therapeutic targeting of this pathway.