Author

Rayk Behrendt

University Hospital BonnORCID 0000-0002-1091-2877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Axel RoersiD· 2 shared Andreas LinkermanniD· 1 shared Angela Rösen‐WolffiD· 1 shared Bastien RiouxiD· 1 shared Björn H. FalkenburgeriD· 1 shared Brendan ConniD· 1 shared C. Mark HilliD· 1 shared Christa HaaseiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

Axel RoersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Decades-long elevation of interferon-alpha drives a Sjogren disease endotype: an interdisciplinary study

Deborah Forbes, Ivana Jorgacevic, Jessica R. Tarn, Katy R Reid, Bastien Rioux, Kyle Thompson, Kilian L. Kleemann, Sarah L. McGlasson, John Casement, Joe Scott Berry, Patrick Müller, Hannah Eberle-Reece, Christa Haase, Brendan Conn, Louis Boon, , David P J Hunt

This study shows that chronic elevation of interferon-alpha drives a specific immune endotype of Sjogren disease, detectable up to 14 years before diagnosis.

bioRxiv · Aug 6, 2025 · PreprintImmunology

Selective inflammation of the tumor microenvironment and invigorated T cell-mediated tumor control upon induced systemic inactivation of TREX1

Emilija Marinković, Minyi Chen, Nadja Schubert, Elif Doğan Dar, Tanja Poth, Janet Y. Leung, Jack Lohre, Jennifer M. Sahni, Christine Tun, Pavithra Rajeswaran, Tanja Mehlo-Jensen, Olivia A. Perng, C. Mark Hill, Pallavur Sivakumar, Michael J. Barnes, , Axel Roers

This study shows that systemic TREX1 inhibition enhances anti-tumor immunity by increasing T cell infiltration and activity in tumors while sparing other tissues.

Cancer Research · May 12, 2025Peer-reviewedImmunology

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

Hella Luksch, Felix Schulze, David Geißler-Lösch, David Sprott, Lennart Höfs, Éva M. Szegő, Wulf Tonnus, Stefan Winkler, Claudia Günther, Andreas Linkermann, Rayk Behrendt, Lino Lars Teichmann, Björn H. Falkenburger, Angela Rösen‐Wolff

This study shows that constitutive STING activation in mice causes SAVI, and TNF signaling mediates its pathogenesis, with TNFR1/2 inhibition improving disease symptoms.

eLife · Mar 20, 2025Peer-reviewedImmunology