High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery
Conor J Howard, Nathan S. Abell, Beatriz A. Osuna, Eric M. Jones, Leon Y Chan, Henry W.-S. Chan, Dean R. Artis, Jonathan B Asfaha, Joshua S. Bloom, Aaron R. Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A. Uribe, , Nathan B. Lubock
This study applies high-resolution deep mutational scanning to the melanocortin-4 receptor to identify functionally significant variants and guide drug development.
eLife · Mar 26, 2025Peer-reviewedSynthetic Biology