Leon Y Chan

High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

This study applies high-resolution deep mutational scanning to the melanocortin-4 receptor to identify functionally significant variants and guide drug development.

Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster

The paper shows that transcriptional interference at the endogenous Adh locus in Drosophila melanogaster is developmentally regulated and tunable through distal promoter activity.

Evidence for an Integrated Gene Repression Mechanism based on mRNA Isoform Toggling in Human Cells

The paper identifies an integrated gene repression mechanism in human cells through mRNA isoform toggling at the MDM2 locus, similar to yeast.

Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

The paper measures mRNA decay in yeast and finds translation initiation, not codon optimality or elongation, determines mRNA stability, with an average half-life of 4.8 minutes.