Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer's disease is resolved by a soluble epoxide hydrolase inhibitor
Anamitra Ghosh, Michele M. Comerota, Debin Wan, Fading Chen, Nicholas E. Propson, Sung Hee Hwang, Bruce D. Hammock, Hui Zheng
The paper shows that soluble epoxide hydrolase is upregulated in AD and that its inhibition restores brain epoxy fatty acids, ameliorates neuropathology, and improves cognitive function.
bioRxiv · Jun 30, 2020 · PreprintNeuroscience