Nicholas E. Propson

This study shows the PD-risk GBA1 variant E326K reduces lysosomal GCase activity by disrupting LIMP2 interaction and causes lysosomal and mitochondrial dysfunction.

This study shows that LRRK2 kinase activity affects BMP and GSL levels in lysosomes, linking lysosomal dysfunction to Parkinson's disease through changes in GCase activity and BMP accumulation.

This study shows that GPR34 regulates microglia function and loss-of-function in TREM2 KO microglia rescues cholesterol metabolism, suggesting GPR34 as a therapeutic target for Alzheimer's disease.

This study identifies type I interferon signaling as a key driver of memory impairment in Alzheimer's disease by promoting neuroinflammation and synaptic loss in a mouse model.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.

The paper shows that soluble epoxide hydrolase is upregulated in AD and that its inhibition restores brain epoxy fatty acids, ameliorates neuropathology, and improves cognitive function.