Hui Zheng

This study identifies an astrocyte-microglia signaling axis in Alzheimer's disease where astrocytic sEH limits EET availability, promoting lysosomal clearance of pSTING and suppressing type I IFN signaling.

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

This study shows that TFEB-v-ATPase signaling regulates lysosomal function and microglial activation in tauopathy by impairing lysosomal acidification and altering microglia responses.

This study identifies type I interferon signaling as a key driver of memory impairment in Alzheimer's disease by promoting neuroinflammation and synaptic loss in a mouse model.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.

The paper shows that soluble epoxide hydrolase is upregulated in AD and that its inhibition restores brain epoxy fatty acids, ameliorates neuropathology, and improves cognitive function.

The paper identifies gene expression signatures in human and mouse brains linked to Alzheimer's disease and finds species-specific and shared patterns across neurodegenerative models.