Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis
Wei Wei, Ruochuan Liu, Jing Zhang, Shu Liu, Antoinette J. Charles, Devash G Asati, Zachary D. Allen, Delance Wright, Kangli Peng, Ellie Krekeler, Nima Mosammaparast, Jun Yin, Angela M. Mabb
The paper identifies RNF216 and OTUD4 as regulators of protein synthesis and degradation, showing their interaction disrupts neurodegeneration in Gordon Holmes syndrome.
bioRxiv · Sep 21, 2026 · PreprintNeuroscience