Angela M. Mabb

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

The paper identifies RNF216 and OTUD4 as regulators of protein synthesis and degradation, showing their interaction disrupts neurodegeneration in Gordon Holmes syndrome.

Engineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin

This study develops an orthogonal ubiquitin transfer cascade to profile Parkin substrates, revealing roles in DNA replication, protein transport, and mitophagy.

Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway

This study shows that tau regulates Arc stability in neuronal dendrites through a proteasome-sensitive, ubiquitin-independent pathway, affecting AMPA receptor localization and synaptic plasticity.

The E3 ubiquitin ligase RNF216 contains a linear ubiquitin chain-determining-like domain that functions to regulate dendritic arborization and dendritic spine type in hippocampal neurons

This study identifies a domain in RNF216 that regulates dendritic arborization and spine morphology through ubiquitin chain assembly, independent of its catalytic activity.

Arc ubiquitination regulates endoplasmic reticulum-mediated Ca2+ release and CaMKII signaling

This study shows that Arc ubiquitination regulates ER-mediated Ca2+ release and CaMKII signaling during mGluR-LTD.

The E3 ubiquitin ligase RNF216/TRIAD3 is a central regulator of the hypothalamic-pituitary-gonadal axis

This study investigates the role of RNF216/TRIAD3 in the hypothalamic-pituitary-gonadal axis using cell line and mouse models, finding sex-specific effects on reproductive function.