Author

Antoinette J. Charles

Georgia State UniversityORCID 0000-0002-5286-5933Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Angela M. MabbiD· 2 shared Jun YiniD· 2 shared Ruochuan LiuiD· 2 shared Delance Wright· 1 shared Devash G Asati· 1 shared Ellie Krekeler· 1 shared Jayashree Kadirvelu· 1 shared Jing Zhang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Angela M. MabbORCID

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2 papers

Recent·Most cited

Substrate Profiling of RNF216 Uncovers a Translation-Linked OTUD4 Regulatory Axis

Wei Wei, Ruochuan Liu, Jing Zhang, Shu Liu, Antoinette J. Charles, Devash G Asati, Zachary D. Allen, Delance Wright, Kangli Peng, Ellie Krekeler, Nima Mosammaparast, Jun Yin, Angela M. Mabb

The paper identifies RNF216 and OTUD4 as regulators of protein synthesis and degradation, showing their interaction disrupts neurodegeneration in Gordon Holmes syndrome.

bioRxiv · Sep 21, 2026 · PreprintNeuroscience

The E3 ubiquitin ligase RNF216 contains a linear ubiquitin chain-determining-like domain that functions to regulate dendritic arborization and dendritic spine type in hippocampal neurons

Jayashree Kadirvelu, Savannah E. Jacobs, Ruochuan Liu, Antoinette J. Charles, Jun Yin, Angela M. Mabb

This study identifies a domain in RNF216 that regulates dendritic arborization and spine morphology through ubiquitin chain assembly, independent of its catalytic activity.

bioRxiv · Oct 19, 2023 · PreprintNeuroscience