Allo-defensive, multiplex base-edited, anti-CD38 CAR T cells for "off-the-shelf" Immunotherapy
Roland Preece, Oliver Gough, Akshay Joshi, Renuka Kadirkamanathan, Eamonn Cudworth, Delordson Kallon, Christos Georgiadis, Waseem Qasim
This paper develops base-edited CAR T cells targeting CD38 to create an off-the-shelf immunotherapy that avoids allo-rejection and shows anti-leukemic activity.
Haematologica · Dec 24, 2025Peer-reviewedImmunology