Oliver Gough

This study compares non-viral and lentiviral CAR-T cell manufacturing, finding comparable in vitro function but lower efficacy and increased exhaustion in non-viral CAR20-T cells in humanised mouse models.

This paper develops base-edited CAR T cells targeting CD38 to create an off-the-shelf immunotherapy that avoids allo-rejection and shows anti-leukemic activity.

This study shows that base edited universal donor CAR T cells targeting multiple antigens can inhibit AML in mice, with combination therapies needed for heterogeneous disease.

The paper identifies ERRFI1 as a novel gene involved in psoriasis and psoriatic arthritis by showing its regulation by a non-coding risk variant at 1p36.23 through enhancer activity in keratinocytes.

The paper identifies gene targets at risk loci for skin-related disorders by integrating HiChIP data from relevant cell lines and public datasets.

This study uses Capture Hi-C and CRISPR activation to identify KLF4 as a target gene in the 9q31 psoriasis risk locus, linking GWAS variants to functional interactions.