Renuka Kadirkamanathan

This study compares non-viral and lentiviral CAR-T cell manufacturing, finding comparable in vitro function but lower efficacy and increased exhaustion in non-viral CAR20-T cells in humanised mouse models.

This paper develops base-edited CAR T cells targeting CD38 to create an off-the-shelf immunotherapy that avoids allo-rejection and shows anti-leukemic activity.

This study shows that base edited universal donor CAR T cells targeting multiple antigens can inhibit AML in mice, with combination therapies needed for heterogeneous disease.