BRD9-containing non-canonical BAF complexes safeguard cell identity and prevent reprogramming
Kenan Sevinç, Gülben Gürhan Sevinç, Ayşe Derya Cavga, Martin Philpott, Simge Kelekçi, Hazal Can, Adam P. Cribbs, Enes Sefa Ayar, Dilşad H. Arabacı, James E. Dunford, Demir Berk Ata, Logan H. Sigua, Jun Qi, Udo C. T. Oppermann, Tamer T. Önder
This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.
bioRxiv · May 27, 2021 · PreprintDevelopmental Biology