Author

Simge Kelekçi

German Cancer Research CenterORCID 0000-0002-4896-0110Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Christoph PlassiD· 2 shared Pavlo LutsikiD· 2 shared Adam P. CribbsiD· 1 shared Alexander Schäffer· 1 shared Anastasija PejkovskaiD· 1 shared Andreas TrumppiD· 1 shared Angelique Schönefeld· 1 shared Ann‐Kathrin EisfeldiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Christoph PlassORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q

Etienne Sollier, Anna Riedel, Umut H. Toprak, Justyna A. Wierzbińska, Dieter Weichenhan, Jan Philipp Schmid, Mariam Hakobyan, Aurore Touzart, Ekaterina Jahn, Binje Vick, Fiona Brown-Burke, Katherine A. Kelly, Simge Kelekçi, Anastasija Pejkovska, Ashish Goyal, , Christoph Plass

Pyjacker detects enhancer hijacking in AML, identifying MNX1 activation via 7q deletion as a novel oncogenic mechanism.

Blood Cancer Discovery · Mar 31, 2025Peer-reviewedCancer Biology

DNMT/G9a Complex Inhibition Uncovers Epigenetic Vulnerabilities and Induces IFN-Response in Acute Myeloid Leukemia

Angelique Schönefeld, Costanza Zanetti, Eric C. Schmitt, Kevin Woods, Ashley Westerback, Sidney M. Mitsch, Frank Rühle, Simge Kelekçi, Lisa Fol, Viral Shah, Miriam Sanchez-Saez, Sophia Thevissen, Alexander Schäffer, Ulrike Regina Schmits, Daniel Sasca, , Borhane Guezguez

This study shows that inhibiting the DNMT/G9a complex targets specific epigenetic vulnerabilities in AML, inducing an IFN response and improving therapeutic outcomes.

bioRxiv · Dec 11, 2024 · PreprintCancer Biology

BRD9-containing non-canonical BAF complexes safeguard cell identity and prevent reprogramming

Kenan Sevinç, Gülben Gürhan Sevinç, Ayşe Derya Cavga, Martin Philpott, Simge Kelekçi, Hazal Can, Adam P. Cribbs, Enes Sefa Ayar, Dilşad H. Arabacı, James E. Dunford, Demir Berk Ata, Logan H. Sigua, Jun Qi, Udo C. T. Oppermann, Tamer T. Önder

This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.

bioRxiv · May 27, 2021 · PreprintDevelopmental Biology