Tamer T. Önder

KLF17 acts as a dual reporter for tracking naive pluripotency and 8-cell-like states

The paper uses KLF17 expression levels to track transitions between primed, naive, and 8-cell-like states in human pluripotent stem cells.

Rapid and efficient generation of human 8-cell-like cells for embryo modelling

This paper develops a method to rapidly generate human 8-cell-like cells (ri8CLCs) using small molecules, enabling efficient modeling of early embryogenesis.

Single-gene knockout of RNLS or HIVEP2 are insufficient to protect β-cell spheroids from allo- and xeno-rejection

This study evaluates if single-gene knockout of RNLS or HIVEP2 can protect β-cell grafts from allo- and xenorejection, finding no protective effects.

Rejuvenation capacity of genetic versus human-optimized chemical reprogramming in cellular aging models

This study compares genetic and chemical reprogramming in human fibroblasts, finding that chemical reprogramming matches or exceeds genetic efficacy while producing more homogeneous outcomes and less cellular stress.

Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer

The paper identifies BRPF1 as a key regulator of Taxol resistance in TNBC through genetic and chemical screens, showing its inhibition sensitizes resistant cells to chemotherapy.

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of H3K79 methylation

This study identifies AF10 as a barrier to somatic cell reprogramming by regulating H3K79 methylation, showing that its suppression enhances reprogramming efficiency.

BRD9-containing non-canonical BAF complexes safeguard cell identity and prevent reprogramming

This study shows that BRD9 and ncBAF complexes maintain somatic cell identity and hinder reprogramming, with BRD9 inhibition increasing iPSC generation efficiency.

NLRP7 Plays A Functional Role in Regulating BMP4 Signaling During Differentiation of Patient-Derived Trophoblasts

This study shows NLRP7 regulates BMP4 signaling in trophoblast differentiation using patient-derived iPSCs, correcting excessive differentiation with BMP pathway inhibition.