Author

Denis Drygin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Adrià ClosaiD· 1 shared Alisee HugloiD· 1 shared Amee J. GeorgeiD· 1 shared Ashlee K. ClarkiD· 1 shared Chad Miller· 1 shared Chang‐Wook LeeiD· 1 shared Eduardo EyrasiD· 1 shared Eric P. KusnadiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Adrià ClosaORCID

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Author profile →

2 papers

Recent·Most cited

The novel RNA polymerase I transcription inhibitor PMR-116 exploits a critical therapeutic vulnerability in a broad-spectrum of high MYC malignancies.

Rita Ferreira, Katherine M. Hannan, Kostya I. Panov, Thejaani P. Udumanne, Amee J. George, Adrià Closa, Zaka Wing-Sze Yuen, Eduardo Eyras, Perlita Poh, Kylee H. Maclachlan, Mitchell Dwyer, Vanessa Barn, Jin-Shu He, Eric P. Kusnadi, Richard J. Rebello, , Nadine Hein

This study shows PMR-116, a second-generation RiBi inhibitor, effectively targets high-MYC cancers without causing DNA damage, suggesting RiBi as a viable cancer therapy.

bioRxiv · Apr 19, 2025 · PreprintCancer Biology

Deep Kernel Inversion: Rapid and Accurate Molecular Interaction Prediction for Drug Design

Seth A. Myers, Chad Miller, Kyler Lugo, Thi Trinh, Chang‐Wook Lee, N. Arunachalam, Hannah Chen, Denis Drygin, James Ian Martineau

This paper introduces a deep learning framework for predicting molecular interactions, reducing computational complexity and demonstrating high performance in human protein-protein interaction mapping.

bioRxiv · Nov 19, 2024 · PreprintSystems Biology