APOBEC3 mutagenesis drives therapy resistance in breast cancer
Avantika Gupta, Andrea M. Gazzo, Pier Selenica, Anton Mikhailovich Safonov, Fresia G. Pareja, Edaise M. da Silva, David N. Brown, Hong Shao, Yingjie Zhu, Juber Patel, Juan Blanco-Heredia, Bojana Stefanovska, Michael A. Carpenter, Yanjun Chen, Isabella Vegas, , Sarat Chandarlapaty
This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.
Nature Genetics · May 16, 2025Peer-reviewedCancer Biology