Yanjun Chen

The paper develops a biosensor to measure UNG activity in living cells and shows mitochondrial UNG1 contributes to nuclear uracil repair.

This study shows that endogenous APOBEC3B causes DNA damage and replication stress, making cancer cells sensitive to CHK1 inhibitors.

This paper introduces collapsing retroviruses (CRVs) to deliver viro-toxic cargoes like APOBEC3B by using recombination to restore gene integrity during transduction, achieving near 100% efficiency.

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

HAMMER is a luminescence-based assay that measures APOBEC3A-mediated RNA editing by detecting changes in luciferase activity ratios.

This study reports the crystal structure of SsdA, a bacterial ssDNA deaminase, revealing its unique substrate binding mechanism and sequence-independent activity.

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

This study models the full-length APOBEC3B structure and finds that NTD-CTD interactions increase active site opening frequency.

The paper develops a real-time biochemical assay to quantify APOBEC3-catalyzed DNA deamination and identify inhibitors.