This paper develops a microfluidic tissue array platform for personalized drug screening using tumor explants or biopsies, showing reduced tumor cell viability and proliferative cell retention after treatment.

bioRxiv · Aug 3, 2026 · PreprintCancer Biology

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Avantika Gupta, Andrea M. Gazzo, Pier Selenica, Anton Mikhailovich Safonov, Fresia G. Pareja, Edaise M. da Silva, David N. Brown, Hong Shao, Yingjie Zhu, Juber Patel, Juan Blanco-Heredia, Bojana Stefanovska, Michael A. Carpenter, Yanjun Chen, Isabella Vegas, , Sarat Chandarlapaty

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

Nature Genetics · May 16, 2025Peer-reviewedCancer Biology

Decoding protein glycosylation by an integrative mass spectrometry-based de novo sequencing strategy

Jing Gao, Hong‐Xu Chen, Hongrui Yin, Xin Chen, Zhicheng Yang, Yuqiu Wang, Jianhong Wu, Yinping Tian, Hong Shao, Liuqing Wen, Hu Zhou

This paper develops a mass spectrometry-based method to decode glycoproteins by integrating deglycosylation and glycosylation site characterization, enabling accurate sequencing of complex glycosylated proteins.

JACS Au · Jan 22, 2025Peer-reviewedBiochemistry

A Genetic Screen for Temperature-sensitive Morphogenesis-defective Caenorhabditis elegans Mutants

Molly C. Jud, Josh Lowry, Thalia Padilla, Erin Clifford, Yuqi Yang, Francesca Fennell, Alexander Miller, Danielle R. Hamill, Austin M. Harvey, Martha Avila-Zavala, Hong Shao, Nhan Nguyen Tran, Zhirong Bao, Bruce A. Bowerman

The paper identifies temperature-sensitive embryonic-lethal mutants in C. elegans with morphogenesis defects and characterizes their genetic and cellular basis.

G3 Genes Genomes Genetics · Mar 13, 2021Peer-reviewedGenetics