Author

David N. Brown

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-8249-3632Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Juber PateliD· 2 shared Marc LadanyiiD· 2 shared Pedram RazaviiD· 2 shared Sarat ChandarlapatyiD· 2 shared Aaron Agarunov· 1 shared Achim A. JungbluthiD· 1 shared Ahmet ZehiriD· 1 shared Aijazuddin SyediD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

Juber PatelORCID

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2 papers

Recent·Most cited

APOBEC3 mutagenesis drives therapy resistance in breast cancer

Avantika Gupta, Andrea M. Gazzo, Pier Selenica, Anton Mikhailovich Safonov, Fresia G. Pareja, Edaise M. da Silva, David N. Brown, Hong Shao, Yingjie Zhu, Juber Patel, Juan Blanco-Heredia, Bojana Stefanovska, Michael A. Carpenter, Yanjun Chen, Isabella Vegas, , Sarat Chandarlapaty

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

Nature Genetics · May 16, 2025Peer-reviewedCancer Biology

Enhanced specificity of high sensitivity somatic variant profiling in cell-free DNA via paired normal sequencing: design, validation, and clinical experience of the MSK-ACCESS liquid biopsy assay

Angela Rose Brannon, Gowtham Jayakumaran, Monica S. Diosdado, Juber Patel, Разумова Анна Ивановна, Yu Hu, Fanli Meng, Mohammad Haque, Justyna Sadowska, Brian J. Murphy, Tessara Baldi, Ian Johnson, Ryan N. Ptashkin, Maysun Hasan, Preethi Srinivasan, , Ryma Benayed

The paper describes the development and clinical application of MSK-ACCESS, a liquid biopsy assay that improves the specificity of somatic variant detection in cell-free DNA by using paired normal sequencing.

bioRxiv · Jun 27, 2020 · PreprintGenomics