Michael A. Carpenter

The paper develops a biosensor to measure UNG activity in living cells and shows mitochondrial UNG1 contributes to nuclear uracil repair.

This study identifies APOBEC3G splicing defects in nonhuman primates that lead to different viral mutation profiles compared to humans.

This study shows that endogenous APOBEC3B causes DNA damage and replication stress, making cancer cells sensitive to CHK1 inhibitors.

This paper introduces collapsing retroviruses (CRVs) to deliver viro-toxic cargoes like APOBEC3B by using recombination to restore gene integrity during transduction, achieving near 100% efficiency.

This paper reports the cryoEM structure of full-length APOBEC3B in complex with BORF2, revealing its domain organization and mechanism of viral neutralization and mutagenesis.

This study identifies APOBEC3 mutagenesis as a common driver of therapy resistance in breast cancer, associated with poorer clinical outcomes.

This study models the full-length APOBEC3B structure and finds that NTD-CTD interactions increase active site opening frequency.

This study shows that carcinogen-induced DNA adducts enhance APOBEC3B-mediated mutagenesis, leading to increased mutation rates in cancer genomes.

The paper develops a real-time biochemical assay to quantify APOBEC3-catalyzed DNA deamination and identify inhibitors.