Author

Derek Pacheco

Fred Hutch Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Organism:yeast· 4 Assay:protein structure· 3 Research Focus:protein structure prediction· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Linda WarfieldiD· 4 shared Steven HahniD· 4 shared Jeffrey A. RanishiD· 2 shared Jie LuoiD· 2 shared Lisa M. TuttleiD· 2 shared Rachel E. KlevitiD· 2 shared Ariel ErijmaniD· 1 shared Damien B. WilburniD· 1 shared

Activity by Year

2018-2021 · peak 2/yr

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10 top collaborators · 30 mutual co-author links

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4 shared papersMolecular Biology

Linda WarfieldORCID

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4 papers

Recent·Most cited

Mediator subunit Med15 dictates the conserved 'fuzzy' binding mechanism of yeast transcription activators Gal4 and Gcn4

Lisa M. Tuttle, Derek Pacheco, Linda Warfield, Damien B. Wilburn, Steven Hahn, Rachel E. Klevit

The paper shows that Gal4 and Gcn4 use a sequence-independent 'fuzzy' binding mechanism to interact with Med15, contrasting with their structured interactions with Gal80.

Nature Communications · Apr 13, 2021Peer-reviewedMolecular Biology

Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA

Rafał Donczew, Linda Warfield, Derek Pacheco, Ariel Erijman, Steven Hahn

The paper identifies two gene classes regulated by TFIID and SAGA in yeast, showing functional redundancy for some genes and distinct dependency for others.

eLife · Jan 8, 2020Peer-reviewedMolecular Biology

Transcription activation domains of the yeast factors Met4 and Ino2: tandem activation domains with properties similar to the yeast Gcn4 activator

Derek Pacheco, Linda Warfield, Michelle R. Brajcich, Hannah F. Robbins, Jie Luo, Jeffrey A. Ranish, Steven Hahn

The paper examines the properties of two yeast transcription activation domains, Met4 and Ino2, showing they interact with Med15 in a heterogeneous manner similar to Gcn4.

Molecular and Cellular Biology · Mar 1, 2018Peer-reviewedMolecular Biology

Transcription activator-coactivator specificity is mediated by a large and dynamic fuzzy protein-protein complex

Lisa M. Tuttle, Derek Pacheco, Linda Warfield, Jie Luo, Jeffrey A. Ranish, Steven Hahn, Rachel E. Klevit

The paper shows that transcription activators form a dynamic fuzzy complex with coactivators through multiple low-affinity interactions, enabling specificity and flexibility in gene regulation.

Cell Reports · Mar 1, 2018Peer-reviewedMolecular Biology