Jie Luo

The paper introduces a novel isobaric crosslinker, Qlinker, for quantitative crosslinking mass spectrometry to study conformational and structural changes in proteins and complexes.

The study identifies specific TAF8 regions critical for TFIID lobe B assembly and TAF2 interactions, showing their necessity for mouse embryonic stem cell survival.

This study presents the structure of the yeast RSC chromatin remodeler, revealing its core and flexible lobes and how it interacts with nucleosomes.

The paper examines the properties of two yeast transcription activation domains, Met4 and Ino2, showing they interact with Med15 in a heterogeneous manner similar to Gcn4.

The paper shows that transcription activators form a dynamic fuzzy complex with coactivators through multiple low-affinity interactions, enabling specificity and flexibility in gene regulation.