Lisa M. Tuttle

This study shows HSPB1 and HSPB5 use distinct N-terminal regions to delay tau aggregation, with HSPB1 under normal conditions and HSPB5 under stress.

This study investigates FimH conformational dynamics and catch bond formation using a single-domain variant, revealing ultra-slow dynamics and a dynamic allosteric mechanism.

This study examines how phosphorylation at different sites in HSPB5 affects its oligomeric structure and function, revealing distinct cellular outcomes based on the extent of phosphorylation.

The paper introduces pyHXExpress, a tool for automated HDX-MS analysis, validated on synthetic data to detect multimodality and characterize protein dynamics.

The paper shows that Gal4 and Gcn4 use a sequence-independent 'fuzzy' binding mechanism to interact with Med15, contrasting with their structured interactions with Gal80.

The paper shows that transcription activators form a dynamic fuzzy complex with coactivators through multiple low-affinity interactions, enabling specificity and flexibility in gene regulation.