Derrick Simet

Spatial MALDI-MSI Reveals a Coordinated Vicious Cycle of Oxidative Membrane Damage and Ceramide-Driven Sphingolipid Dysregulation in the Chronically Neuroinflamed Brain

This study uses MALDI-MSI to show that chronic neuroinflammation causes spatial lipidomic changes in rat brains, including oxidative stress and sphingolipid dysregulation, particularly in the hippocampus and white matter.

Age-Dependent Spatiotemporal Remodeling of Brain Sphingolipids During LPS-Induced Neuroinflammation: MALDI-MSI Reveals Accelerated Sphingomyelin Depletion and Sulfatide Accumulation Linked to Mitochondrial Oxidative Stress

This study uses MALDI-MSI to show age-dependent sphingolipid changes in rat brains after LPS, linking sphingomyelin loss and sulfatide gain to mitochondrial stress.

Chronic Paraventricular OX1R Overexpression Induces Oxidative Stress and Hypertension in Rats

This study shows that chronic overexpression of OX1R in the PVN of rats leads to hypertension, oxidative stress, and increased sympathetic activity.