Zhiying Jenny Shan

The paper compares brain and kidney extracellular vesicle morphology and proteomics after inflammatory challenge, identifying significant protein changes but noting limitations in causal conclusions.

This study uses MALDI-MSI to show that chronic neuroinflammation causes spatial lipidomic changes in rat brains, including oxidative stress and sphingolipid dysregulation, particularly in the hippocampus and white matter.

This study uses MALDI-MSI to show age-dependent sphingolipid changes in rat brains after LPS, linking sphingomyelin loss and sulfatide gain to mitochondrial stress.

This study shows that chronic overexpression of OX1R in the PVN of rats leads to hypertension, oxidative stress, and increased sympathetic activity.

This paper uses copper-free click chemistry to engineer mitochondria-targeted brain-derived exosomes, preserving their structure and function while enabling targeted delivery and imaging.

The paper introduces MitoFlare, a reversible mitochondrial ROS probe, and demonstrates its application in quantifying mitophagy dynamics in real time using a dual-probe imaging platform.

This paper introduces a novel mitochondrial-targeting dye, Cy5-PEG4, for in vivo brain imaging and neurodegenerative disease studies, showing improved BBB penetration and reduced toxicity.

The paper develops a mitochondria-targeting fluorescent dye, Cy5-PEG2, for in vivo brain imaging and assesses its safety in brain regions.

This study designs and evaluates mitochondria-targeting exosomes for treating brain tumors and neurodegenerative diseases using in vitro and in vivo tests.

This study investigates the therapeutic potential of IADB in ALS models, showing it promotes autophagy and reduces mutant SOD1 aggregates, oxidative stress, and disease progression.