Xinqian Chen

Comparative Proteomics Reveals Cell-Type-Specific Heterogeneity of Human Neural Cell-Derived Extracellular Vesicles

The paper compares proteomic profiles of extracellular vesicles from different human neural cell types to identify cell-type-specific cargo and functional roles.

Chronic Paraventricular OX1R Overexpression Induces Oxidative Stress and Hypertension in Rats

This study shows that chronic overexpression of OX1R in the PVN of rats leads to hypertension, oxidative stress, and increased sympathetic activity.

Copper-Free Click Chemistry Enables High-Fidelity Engineering of Mitochondria Targeted Brain-Derived Exosomes

This paper uses copper-free click chemistry to engineer mitochondria-targeted brain-derived exosomes, preserving their structure and function while enabling targeted delivery and imaging.

A Novel Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging in Neurotoxic Conditions and In Vivo Brain Studies

This paper introduces a novel mitochondrial-targeting dye, Cy5-PEG4, for in vivo brain imaging and neurodegenerative disease studies, showing improved BBB penetration and reduced toxicity.

Targeting and Imaging Mitochondria with a Novel Cyanine-based Fluorescent Dye and Its Application to Whole Brain Imaging

The paper develops a mitochondria-targeting fluorescent dye, Cy5-PEG2, for in vivo brain imaging and assesses its safety in brain regions.

Design, Synthesis, and Biological Evaluation of Novel Mitochondria-targeting Exosomes

This study designs and evaluates mitochondria-targeting exosomes for treating brain tumors and neurodegenerative diseases using in vitro and in vivo tests.